For a more complete and up-to-date publication list, please visit this page.

2019

  • Essential Characteristics of Pharmacogenomics Study Publications. CLINICAL PHARMACOLOGY AND THERAPEUTICS. Thorn C.F., Whirl-Carrillo M., Hachad H., Johnson J.A., McDonagh E.M., Ratain M.J., Relling M.V., Scott S.A., Altman R.B. and Klein T.E. 2019; 105: 86--91
  • Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals. CLINICAL PHARMACOLOGY AND THERAPEUTICS. Danese E. et al. 2019; 105: 1477--1491
  • Examining the Use of Real-World Evidence in the Regulatory Process. CLINICAL PHARMACOLOGY AND THERAPEUTICS. Beaulieu-Jones B.K., Finlayson S., Yuan W., Altman R.B., Kohane I.S., Prasad V. and Yu K. 2019
  • Research Projects Supported by the University of California, San Francisco-Stanford Center of Excellence in Regulatory Science and Innovation. CLINICAL PHARMACOLOGY AND THERAPEUTICS. Giacomini K.M., Lin L. and Altman R.B. 2019; 105: 815--818
  • High precision protein functional site detection using 3D convolutional neural networks. BIOINFORMATICS (OXFORD, ENGLAND). Torng W. and Altman R.B. 2019; 35: 1503--1512
  • Standardized Biogeographic Grouping System for Annotating Populations in Pharmacogenetic Research. CLINICAL PHARMACOLOGY AND THERAPEUTICS. Huddart R., Fohner A.E., Whirl-Carrillo M., Wojcik G.L., Gignoux C.R., Popejoy A.B., Bustamante C.D., Altman R.B. and Klein T.E. 2019; 105: 1256--1262
  • Pharmacogenomics in dermatology: tools for understanding gene-drug associations. SEMINARS IN CUTANEOUS MEDICINE AND SURGERY. Daneshjou R., Huddart R., Klein T.E. and Altman R.B. 2019; 38: E19--E24
  • Graph Convolutional Neural Networks for Predicting Drug-Target Interactions. JOURNAL OF CHEMICAL INFORMATION AND MODELING. Torng W. and Altman R.B. 2019
  • Predicting HLA class II antigen presentation through integrated deep learning. NATURE BIOTECHNOLOGY. Chen B., Khodadoust M.S., Olsson N., Wagar L.E., Fast E., Liu C.Long., Muftuoglu Y., Sworder B.J., Diehn M., Levy R., Davis M.M., Elias J.E., Altman R.B. and Alizadeh A.A. 2019
  • The association of obesity and coronary artery disease genes with response to SSRIs treatment in major depression. JOURNAL OF NEURAL TRANSMISSION (VIENNA, AUSTRIA : 1996). Amare A.T. et al. 2019; 126: 35--45
  • Atrial Fibrillation Burden Signature and Near-Term Prediction of Stroke: A Machine Learning Analysis. CIRCULATION. CARDIOVASCULAR QUALITY AND OUTCOMES. Han L., Askari M., Altman R.B., Schmitt S.K., Fan J., Bentley J.P., Narayan S.M. and Turakhia M.P. 2019; 12: e005595
  • Computational analysis of kinase inhibitor selectivity using structural knowledge. BIOINFORMATICS (OXFORD, ENGLAND). Lo Y., Liu T., Morrissey K.M., Kakiuchi-Kiyota S., Johnson A.R., Broccatelli F., Zhong Y., Joshi A. and Altman R.B. 2019; 35: 235--242
  • PathFXweb: a web application for identifying drug safety and efficacy phenotypes. BIOINFORMATICS (OXFORD, ENGLAND). Wilson J.L., Wong M., Chalke A., Stepanov N., Petkovic D. and Altman R.B. 2019
  • Predicting venous thromboembolism risk from exomes in the Critical Assessment of Genome Interpretation (CAGI) challenges. HUMAN MUTATION. McInnes G. et al. 2019; 40: 1314--1320
  • RedMed: Extending drug lexicons for social media applications JOURNAL OF BIOMEDICAL INFORMATICS. Lavertu A. and Altman R.B. 2019
  • Pharmacogenomic Polygenic Response Score Predicts Ischemic Events and Cardiovascular Mortality in Clopidogrel-Treated Patients. EUROPEAN HEART JOURNAL. CARDIOVASCULAR PHARMACOTHERAPY. Lewis J.P., Backman J.D., Reny J., Bergmeijer T.O., Mitchell B.D., Ritchie M.D., Dery J., Pakyz R.E., Gong L., Ryan K., Kim E., Aradi D., Fernandez-Cadenas I., Whaley R.M., Montaner J., Gensini G.Franco., Cleator J.H., Chang K., Holmvang L., Hochholzer W., Roden D.M., Winter S., Altman R., Alexopoulos D., Kim H., Gawaz M., Bliden K., Valgimigli M., Marcucci R., Campo G., Schaeffeler E., Dridi N.P., Wen M., Shin J.Gook., Fontana P., Giusti B., Geisler T., Kubo M., Trenk D., Siller-Matula J.M., Ten Berg J.M., Gurbel P.A., Schwab M., Klein T.E. and Shuldiner A.R. 2019
  • PharmGKB summary: Ondansetron and tropisetron pathways, pharmacokinetics and pharmacodynamics. PHARMACOGENETICS AND GENOMICS. Huddart R., Altman R.B. and Klein T.E. 2019; 29: 91--97
  • Pocket similarity identifies selective estrogen receptor modulators as microtubule modulators at the taxane site. NATURE COMMUNICATIONS. Lo Y., Cormier O., Liu T., Nettles K.W., Katzenellenbogen J.A., Stearns T. and Altman R.B. 2019; 10: 1033
  • Pharmacogenomics Clinical Annotation Tool (PharmCAT). CLINICAL PHARMACOLOGY AND THERAPEUTICS. Sangkuhl K., Whirl-Carrillo M., Whaley R.M., Woon M., Lavertu A., Altman R.B., Carter L., Verma A., Ritchie M.D. and Klein T.E. 2019
  • #Science: The Potential and the Challenges of Utilizing Social Media and Other Electronic Communication Platforms in Health Care. CLINICAL AND TRANSLATIONAL SCIENCE. Gijsen V., Maddux M., Lavertu A., Gonzalez-Hernandez G., Ram N., Reeves B., Robinson T., Ziesenitz V., Shacitations(37).nbibkhnovich V. and Altman R. 2019
  • PharmGKB summary: methylphenidate pathway, pharmacokinetics/pharmacodynamics. PHARMACOGENETICS AND GENOMICS. Stevens T., Sangkuhl K., Brown J.T., Altman R.B. and Klein T.E. 2019

2018

  • Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals. CLINICAL PHARMACOLOGY AND THERAPEUTICS. Danese E., Raimondi S., Montagnana M., Tagetti A., Langaee T., Borgiani P., Ciccacci C., Carcas A.J., Borobia A.M., Tong H.Y., Davila-Fajardo C., Rodrigues Botton M., Bourgeois S., Deloukas P., Caldwell M.D., Burmester J.K., Berg R.L., Cavallari L.H., Drozda K., Huang M., Zhao L., Cen H., Gonzalez-Conejero R., Roldan V., Nakamura Y., Mushiroda T., Gong I.Y., Kim R.B., Hirai K., Itoh K., Isaza C., Beltran L., Jimenez-Varo E., Canadas-Garre M., Giontella A., Kringen M.K., Gwak H.Sun., Lee K.Eun., Minuz P., Lubitz S.A., Scott S., Mazzaccara C., Sacchetti L., Genc E., Ozer M., Pathare A., Krishnamoorthy R., Paldi A., Siguret V., Loriot M., Kutala V.Kumar., Suarez-Kurtz G., Perini J., Denny J.C., Ramirez A.H., Mittal B., Rathore S.Singh., Sagreiya H., Altman R., Khalifa S.I., Limdi N.A., Rivers C., Shendre A., Dillon C., Suriapranata I.M., Zhou H., Tan S., Tatarunas V., Lesauskaite V., Zhang Y., Maitland-van der Zee A.H., Verhoef T.I., de Boer A., Taljaard M., Zambon C.Federico., Pengo V., Zhang J.Eunice., Pirmohamed M., Johnson J.A. and Fava C. 2018
  • A dynamic map for learning, communicating, navigating and improving therapeutic development. NATURE REVIEWS. DRUG DISCOVERY. Wagner J., Dahlem A.M., Hudson L.D., Terry S.F., Altman R.B., Gilliland C.Taylor., DeFeo C. and Austin C.P. 2018; 17: 150
  • Application of a Dynamic Map for Learning, Communicating, Navigating, and Improving Therapeutic Development. CLINICAL AND TRANSLATIONAL SCIENCE. Wagner J.A., Dahlem A.M., Hudson L.D., Terry S.F., Altman R.B., Gilliland C.Taylor., DeFeo C. and Austin C.P. 2018; 11: 166--174
  • A probabilistic pathway score (PROPS) for classification with applications to inflammatory bowel disease. BIOINFORMATICS (OXFORD, ENGLAND). Han L., Maciejewski M., Brockel C., Gordon W., Snapper S.B., Korzenik J.R., Afzelius L. and Altman R.B. 2018; 34: 985--993
  • Systematic target function annotation of human transcription factors. BMC BIOLOGY. Li Y.Fuga. and Altman R.B. 2018; 16: 4
  • The Pioglitazone Trek via Human PPAR Gamma: From Discovery to a Medicine at the FDA and Beyond. FRONTIERS IN PHARMACOLOGY. Devchand P.R., Liu T., Altman R.B., FitzGerald G.A. and Schadt E.E. 2018; 9: 1093
  • PharmGKB summary: clozapine pathway, pharmacokinetics. PHARMACOGENETICS AND GENOMICS. Thorn C.F., Muller D.J., Altman R.B. and Klein T.E. 2018; 28: 214--222
  • A global network of biomedical relationships derived from text. BIOINFORMATICS (OXFORD, ENGLAND). Percha B. and Altman R.B. 2018
  • Biomarkers: Delivering on the expectation of molecularly driven, quantitative health. EXPERIMENTAL BIOLOGY AND MEDICINE (MAYWOOD, N.J.). Wilson J.L. and Altman R.B. 2018; 243: 313--322
  • Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC). AMERICAN HEART JOURNAL. Bergmeijer T.O., Reny J., Pakyz R.E., Gong L., Lewis J.P., Kim E., Aradi D., Fernandez-Cadenas I., Horenstein R.B., Whaley R.M., Montaner J., Gensini G.Franco., Cleator J.H., Chang K., Holmvang L., Hochholzer W., Roden D.M., Winter S., Altman R.B., Alexopoulos D., Kim H., Dery J., Gawaz M., Bliden K., Valgimigli M., Marcucci R., Campo G., Schaeffeler E., Dridi N.P., Wen M., Shin J.Gook., Simon T., Fontana P., Giusti B., Geisler T., Kubo M., Trenk D., Siller-Matula J.M., Ten Berg J.M., Gurbel P.A., Hulot J., Mitchell B.D., Schwab M., Ritchie M.DeRiggi., Klein T.E. and Shuldiner A.R. 2018; 198: 152--159
  • Pharmacogenomics and big genomic data: from lab to clinic and back again. HUMAN MOLECULAR GENETICS. Lavertu A., McInnes G., Daneshjou R., Whirl-Carrillo M., Klein T.E. and Altman R.B. 2018
  • PharmGKB: A worldwide resource for pharmacogenomic information. WILEY INTERDISCIPLINARY REVIEWS. SYSTEMS BIOLOGY AND MEDICINE. Barbarino J.M., Whirl-Carrillo M., Altman R.B. and Klein T.E. 2018
  • Data-driven human transcriptomic modules determined by independent component analysis. BMC BIOINFORMATICS. Zhou W. and Altman R.B. 2018; 19: 327
  • Reversals and limitations on high-intensity, life-sustaining treatments. PLOS ONE. Chavez G., Richman I.B., Kaimal R., Bentley J., Yasukawa L.Ann., Altman R.B., Periyakoil V.S. and Chen J.H. 2018; 13: e0190569
  • Machine learning in chemoinformatics and drug discovery. DRUG DISCOVERY TODAY. Lo Y., Rensi S.E., Torng W. and Altman R.B. 2018; 23: 1538--1546
  • PharmGKB summary: atazanavir pathway, pharmacokinetics/pharmacodynamics. PHARMACOGENETICS AND GENOMICS. Alvarellos M., Guillemette C., Altman R.B. and Klein T.E. 2018
  • Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder. FRONTIERS IN PSYCHIATRY. Amare A.T., Schubert K.Oliver., Tekola-Ayele F., Hsu Y., Sangkuhl K., Jenkins G., Whaley R.M., Barman P., Batzler A., Altman R.B., Arolt V., Brockmoller J., Chen C., Domschke K., Hall-Flavin D.K., Hong C., Illi A., Ji Y., Kampman O., Kinoshita T., Leinonen E., Liou Y., Mushiroda T., Nonen S., Skime M.K., Wang L., Kato M., Liu Y., Praphanphoj V., Stingl J.C., Bobo W.V., Tsai S., Kubo M., Klein T.E., Weinshilboum R.M., Biernacka J.M. and Baune B.T. 2018; 9: 65
  • Chemical reaction vector embeddings: towards predicting drug metabolism in the human gut microbiome. PACIFIC SYMPOSIUM ON BIOCOMPUTING. PACIFIC SYMPOSIUM ON BIOCOMPUTING. Mallory E.K., Acharya A., Rensi S.E., Turnbaugh P.J., Bright R.A. and Altman R.B. 2018; 23: 56--67
  • Expanding a radiology lexicon using contextual patterns in radiology reports. JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION : JAMIA. Percha B., Zhang Y., Bozkurt S., Rubin D., Altman R.B. and Langlotz C.P. 2018
  • PathFX provides mechanistic insights into drug efficacy and safety for regulatory review and therapeutic development. PLOS COMPUTATIONAL BIOLOGY. Wilson J.L., Racz R., Liu T., Adeniyi O., Sun J., Ramamoorthy A., Pacanowski M. and Altman R. 2018; 14: e1006614
  • Biological and functional relevance of CASP predictions. PROTEINS. Liu T., Ish-Shalom S., Torng W., Lafita A., Bock C., Mort M., Cooper D.N., Bliven S., Capitani G., Mooney S.D. and Altman R.B. 2018; 86 Suppl 1: 374--386
  • Mendelian Disease Associations Reveal Novel Insights into Inflammatory Bowel Disease. INFLAMMATORY BOWEL DISEASES. Han L., Maciejewski M., Brockel C., Afzelius L. and Altman R.B. 2018; 24: 471--481
  • PharmGKB summary: clobazam pathway, pharmacokinetics. PHARMACOGENETICS AND GENOMICS. Huddart R., Leeder J.Steven., Altman R.B. and Klein T.E. 2018; 28: 110--115
  • Challenges for Training Translational Researchers in the Era of Ubiquitous Data. CLINICAL PHARMACOLOGY AND THERAPEUTICS. Altman R.B. 2018; 103: 171--173
  • PharmGKB summary: oxycodone pathway, pharmacokinetics. PHARMACOGENETICS AND GENOMICS. Huddart R., Clarke M., Altman R.B. and Klein T.E. 2018; 28: 230--237

2017

  • Working toward precision medicine: Predicting phenotypes from exomes in the Critical Assessment of Genome Interpretation (CAGI) challenges. HUMAN MUTATION. Daneshjou R., Wang Y., Bromberg Y., Bovo S., Martelli P.L., Babbi G., Lena P.Di., Casadio R., Edwards M., Gifford D., Jones D.T., Sundaram L., Bhat R.Rana., Li X., Pal L.R., Kundu K., Yin Y., Moult J., Jiang Y., Pejaver V., Pagel K.A., Li B., Mooney S.D., Radivojac P., Shah S., Carraro M., Gasparini A., Leonardi E., Giollo M., Ferrari C., Bachar E., Azaria J.R., Ofran Y., Unger R., Niroula A., Vihinen M., Chang B., Wang M.H., Franke A., Petersen B., Pirooznia M., Zandi P., McCombie R., Potash J.B., Altman R.B., Klein T.E., Hoskins R.A., Repo S., Brenner S.E. and Morgan A.A. 2017; 38: 1182--1192
  • Artificial intelligence (AI) systems for interpreting complex medical datasets. CLINICAL PHARMACOLOGY AND THERAPEUTICS. Altman R.B. 2017; 101: 585--586
  • Opportunities for developing therapies for rare genetic diseases: focus on gain-of-function and allostery. ORPHANET JOURNAL OF RARE DISEASES. Chen B. and Altman R.B. 2017; 12: 61
  • The Pharmacogenomics Research Network Translational Pharmacogenetics Program: Outcomes and Metrics of Pharmacogenetic Implementations Across Diverse Healthcare Systems. CLINICAL PHARMACOLOGY AND THERAPEUTICS. Luzum J.A., Pakyz R.E., Elsey A.R., Haidar C.E., Peterson J.F., Whirl-Carrillo M., Handelman S.K., Palmer K., Pulley J.M., Beller M., Schildcrout J.S., Field J.R., Weitzel K.W., Cooper-DeHoff R.M., Cavallari L.H., O'Donnell P.H., Altman R.B., Pereira N., Ratain M.J., Roden D.M., Embi P.J., Sadee W., Klein T.E., Johnson J.A., Relling M.V., Wang L., Weinshilboum R.M., Shuldiner A.R. and Freimuth R.R. 2017; 102: 502--510
  • PharmGKB summary: voriconazole pathway, pharmacokinetics. PHARMACOGENETICS AND GENOMICS. Barbarino J.M., Owusu Obeng A., Klein T.E. and Altman R.B. 2017; 27: 201--209
  • Pharmacogenomics-Based Point-of-Care Clinical Decision Support Significantly Alters Drug Prescribing. CLINICAL PHARMACOLOGY AND THERAPEUTICS. O'Donnell P.H., Wadhwa N., Danahey K., Borden B.A., Lee S.M., Hall J.P., Klammer C., Hussain S., Siegler M., Sorrentino M.J., Davis A.M., Sacro Y.A., Nanda R., Polonsky T.S., Koyner J.L., Burnet D.L., Lipstreuer K., Rubin D.T., Mulcahy C., Strek M.E., Harper W., Cifu A.S., Polite B., Patrick-Miller L., Yeo K., Leung E., Volchenboum S.L., Altman R.B., Olopade O.I., Stadler W.M., Meltzer D.O. and Ratain M.J. 2017
  • PharmGKB summary: sorafenib pathways. PHARMACOGENETICS AND GENOMICS. Gong L., Giacomini M.M., Giacomini C., Maitland M.L., Altman R.B. and Klein T.E. 2017; 27: 240--246
  • Imputing gene expression to maximize platform compatibility. BIOINFORMATICS (OXFORD, ENGLAND). Zhou W., Han L. and Altman R.B. 2017; 33: 522--528
  • PharmGKB summary: pazopanib pathway, pharmacokinetics. PHARMACOGENETICS AND GENOMICS. Thorn C.F., Sharma M.R., Altman R.B. and Klein T.E. 2017; 27: 307--312
  • PharmGKB summary: Macrolide antibiotic pathway, pharmacokinetics/pharmacodynamics. PHARMACOGENETICS AND GENOMICS. Fohner A.E., Sparreboom A., Altman R.B. and Klein T.E. 2017; 27: 164--167
  • 3D deep convolutional neural networks for amino acid environment similarity analysis. BMC BIOINFORMATICS. Torng W. and Altman R.B. 2017; 18: 302
  • PharmGKB summary: very important pharmacogene information for ABCG2. PHARMACOGENETICS AND GENOMICS. Fohner A.E., Brackman D.J., Giacomini K.M., Altman R.B. and Klein T.E. 2017
  • Shallow Representation Learning via Kernel PCA Improves QSAR Modelability. JOURNAL OF CHEMICAL INFORMATION AND MODELING. Rensi S.E. and Altman R.B. 2017; 57: 1859--1867
  • Development of an automated assessment tool for MedWatch reports in the FDA adverse event reporting system. JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION : JAMIA. Han L., Ball R., Pamer C.A., Altman R.B. and Proestel S. 2017; 24: 913--920
  • Decaying relevance of clinical data towards future decisions in data-driven inpatient clinical order sets. INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS. Chen J.H., Alagappan M., Goldstein M.K., Asch S.M. and Altman R.B. 2017; 102: 71--79
  • Flexible Analog Search with Kernel PCA Embedded Molecule Vectors. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL. Rensi S. and Altman R.B. 2017; 15: 320--327

2016

  • Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity. NATURE MEDICINE. Burridge P.W., Li Y.Fuga., Matsa E., Wu H., Ong S., Sharma A., Holmstrom A., Chang A.C., Coronado M.J., Ebert A.D., Knowles J.W., Telli M.L., Witteles R.M., Blau H.M., Bernstein D., Altman R.B. and Wu J.C. 2016; 22: 547--556
  • DYNAMICALLY EVOLVING CLINICAL PRACTICES AND IMPLICATIONS FOR PREDICTING MEDICAL DECISIONS. PACIFIC SYMPOSIUM ON BIOCOMPUTING. PACIFIC SYMPOSIUM ON BIOCOMPUTING. Chen J.H., Goldstein M.K., Asch S.M. and Altman R.B. 2016; 21: 195--206
  • PharmGKB summary: very important pharmacogene information for MT-RNR1. PHARMACOGENETICS AND GENOMICS. Barbarino J.M., McGregor T.L., Altman R.B. and Klein T.E. 2016; 26: 558--567
  • Constraints on Biological Mechanism from Disease Comorbidity Using Electronic Medical Records and Database of Genetic Variants. PLOS COMPUTATIONAL BIOLOGY. Bagley S.C., Sirota M., Chen R., Butte A.J. and Altman R.B. 2016; 12: e1004885
  • Response to Open Peer Commentaries on "Human Germline CRISPR-Cas Modification: Toward a Regulatory Framework". THE AMERICAN JOURNAL OF BIOETHICS : AJOB. Evitt N.H., Mascharak S. and Altman R.B. 2016; 16: W1--2
  • Population-specific single-nucleotide polymorphism confers increased risk of venous thromboembolism in African Americans. MOLECULAR GENETICS \& GENOMIC MEDICINE. Daneshjou R., Cavallari L.H., Weeke P.E., Karczewski K.J., Drozda K., Perera M.A., Johnson J.A., Klein T.E., Bustamante C.D., Roden D.M., Shaffer C., Denny J.C., Zehnder J.L. and Altman R.B. 2016; 4: 513--520
  • Predicting non-small cell lung cancer prognosis by fully automated microscopic pathology image features. NATURE COMMUNICATIONS. Yu K., Zhang C., Berry G.J., Altman R.B., Re C., Rubin D.L. and Snyder M. 2016; 7: 12474
  • STAMS: STRING-assisted module search for genome wide association studies and application to autism. BIOINFORMATICS (OXFORD, ENGLAND). Hillenmeyer S., Davis L.K., Gamazon E.R., Cook E.H., Cox N.J. and Altman R.B. 2016; 32: 3815--3822
  • Computing disease incidence, prevalence and comorbidity from electronic medical records. JOURNAL OF BIOMEDICAL INFORMATICS. Bagley S.C. and Altman R.B. 2016; 63: 108--111
  • Predicting inpatient clinical order patterns with probabilistic topic models vs conventional order sets. JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION : JAMIA. Chen J.H., Goldstein M.K., Asch S.M., Mackey L. and Altman R.B. 2017; 24: 472--480
  • PharmGKB summary: ivacaftor pathway, pharmacokinetics/pharmacodynamics. PHARMACOGENETICS AND GENOMICS. Fohner A.E., McDonagh E.M., Clancy J.P., Whirl Carrillo M., Altman R.B. and Klein T.E. 2017; 27: 39--42
  • Towards Clinical Bioinformatics: Redux 2015. YEARBOOK OF MEDICAL INFORMATICS. Altman R.B. 2016; Suppl 1: S6--7
  • Estimation of Maximum Recommended Therapeutic Dose Using Predicted Promiscuity and Potency. CLINICAL AND TRANSLATIONAL SCIENCE. Liu T., Oprea T., Ursu O., Hasselgren C. and Altman R.B. 2016; 9: 311--320
  • A research roadmap for next-generation sequencing informatics. SCIENCE TRANSLATIONAL MEDICINE. Altman R.B., Prabhu S., Sidow A., Zook J.M., Goldfeder R., Litwack D., Ashley E., Asimenos G., Bustamante C.D., Donigan K., Giacomini K.M., Johansen E., Khuri N., Lee E., Liang X.Sharon., Salit M., Serang O., Tezak Z., Wall D.P., Mansfield E. and Kass-Hout T. 2016; 8: 335ps10
  • PharmGKB summary: very important pharmacogene information for RYR1. PHARMACOGENETICS AND GENOMICS. Alvarellos M.L., Krauss R.M., Wilke R.A., Altman R.B. and Klein T.E. 2016; 26: 138--144
  • SEPARATING THE CAUSES AND CONSEQUENCES IN DISEASE TRANSCRIPTOME. PACIFIC SYMPOSIUM ON BIOCOMPUTING. PACIFIC SYMPOSIUM ON BIOCOMPUTING. Li Y.Fuga., Xin F. and Altman R.B. 2016; 21: 381--392
  • PharmGKB summary: isoniazid pathway, pharmacokinetics. PHARMACOGENETICS AND GENOMICS. Klein D.J., Boukouvala S., McDonagh E.M., Shuldiner S.R., Laurieri N., Thorn C.F., Altman R.B. and Klein T.E. 2016; 26: 436--444

2015

  • Human Germline CRISPR-Cas Modification: Toward a Regulatory Framework. AMERICAN JOURNAL OF BIOETHICS. Evitt, N. H., Mascharak, S., Altman, R. B. 2015; 15 (12): 25-29
  • Unmet needs: Research helps regulators do their jobs. SCIENCE TRANSLATIONAL MEDICINE. Altman, R. B., Khuri, N., Salit, M., Giacomini, K. M.
  • Sequence to Medical Phenotypes: A Framework for Interpretation of Human Whole Genome DNA Sequence Data. PLoS genetics. Dewey, F. E., Grove, M. E., Priest, J. R., Waggott, D., Batra, P., Miller, C. L., Wheeler, M., Zia, A., Pan, C., Karzcewski, K. J., Miyake, C., Whirl-Carrillo, M., Klein, T. E., Datta, S., Altman, R. B., Snyder, M., Quertermous, T., Ashley, E. A. 2015; 11 (10)
  • Sequence to Medical Phenotypes: A Framework for Interpretation of Human Whole Genome DNA Sequence Data. PLOS GENETICS Dewey, F. E., Grove, M. E., Priest, J. R., Waggott, D., Batra, P., Miller, C. L., Wheeler, M., Zia, A., Pan, C., Karzcewski, K. J., Miyake, C., Whirl-Carrillo, M., Klein, T. E., Datta, S., Altman, R. B., Snyder, M., Quertermous, T., Ashley, E. A. 2015; 11 (10)
  • PharmGKB summary: peginterferon-alpha pathway. PHARMACOGENETICS AND GENOMICS. Shuldiner, S. R., Gong, L., Muir, A. J., Altman, R. B., Klein, T. E. 2015; 25 (9): 465-474
  • High Resolution Prediction of Calcium-Binding Sites in 3D Protein Structures Using FEATURE. Journal of chemical information and modeling. Zhou, W., Tang, G. W., Altman, R. B. 2015; 55 (8): 1663-1672
  • Learning the Structure of Biomedical Relationships from Unstructured Text. PLoS computational biology. Percha, B., Altman, R. B. 2015; 11 (7)
  • Relating Essential Proteins to Drug Side-Effects Using Canonical Component Analysis: A Structure-Based Approach. JOURNAL OF CHEMICAL INFORMATION AND MODELING. Liu, T., Altman, R. B. 2015; 55 (7): 1483-1494

Before 2015

  • PharmGKB summary: gemcitabine pathway. PHARMACOGENETICS AND GENOMICS. Alvarellos, M. L., Lamba, J., Sangkuhl, K., Thorn, C. F., Wang, L., Klein, D. J., Altman, R. B., Klein, T. E. 2014; 24 (11): 564-574
  • Genetic variant in folate homeostasis is associated with lower warfarin dose in African Americans. BLOOD. Daneshjou, R., Gamazon, E. R., Burkley, B., Cavallari, L. H., Johnson, J. A., Klein, T. E., Limdi, N., Hillenmeyer, S., Percha, B., Karczewski, K. J., Langaee, T., Patel, S. R., Bustamante, C. D., Altman, R. B., Perera, M. A. 2014; 124 (14): 2298-2305
  • PharmGKB summary: uric acid-lowering drugs pathway, pharmacodynamics. PHARMACOGENETICS AND GENOMICS. McDonagh, E. M., Thorn, C. F., Callaghan, J. T., Altman, R. B., Klein, T. E. 2014; 24 (9): 464-476
  • PharmGKB summary: very important pharmacogene information for N-acetyltransferase 2. PHARMACOGENETICS AND GENOMICS. McDonagh, E. M., Boukouvala, S., Aklillu, E., Hein, D. W., Altman, R. B., Klein, T. E. 2014; 24 (8): 409-425
  • Interpreting the CYP2D6 results from the International Tamoxifen Pharmacogenetics Consortium. Clinical pharmacology & therapeutics. Province, M. A., Altman, R. B., Klein, T. E. 2014; 96 (2): 144-146
  • Integrating Systems Biology Sources Illuminates Drug Action. CLINICAL PHARMACOLOGY & THERAPEUTICS. Gottlieb, A., Altman, R. B. 2014; 95 (6): 663-669
  • Reconstruction of the Mouse Otocyst and Early Neuroblast Lineage at Single-Cell Resolution. CELL. Durruthy-Durruthy, R., Gottlieb, A., Hartman, B. H., Waldhaus, J., Laske, R. D., Altman, R., Heller, S. 2014; 157 (4): 964-978
  • Translational Bioinformatics: Linking the Molecular World to the Clinical World. CLINICAL PHARMACOLOGY & THERAPEUTICS. Altman, R. B. 2012; 91 (6): 994-1000
  • Data-Driven Prediction of Drug Effects and Interactions. SCIENCE TRANSLATIONAL MEDICINE. Tatonetti, N. P., Ye, P. P., Daneshjou, R., Altman, R. B. 2012; 4 (125)
  • Clinical assessment incorporating a personal genome. LANCET. Ashley, E. A., Butte, A. J., Wheeler, M. T., Chen, R., Klein, T. E., Dewey, F. E., Dudley, J. T., Ormond, K. E., Pavlovic, A., Morgan, A. A., Pushkarev, D., Neff, N. F., Hudgins, L., Gong, L., Hodges, L. M., Berlin, D. S., Thorn, C. F., Sangkuhl, K., Hebert, J. M., Woon, M., Sagreiya, H., Whaley, R., Knowles, J. W., Chou, M. F., Thakuria, J. V., Rosenbaum, A. M., Zaranek, A. W., Church, G. M., Greely, H. T., Quake, S. R., Altman, R. B. 2010; 375 (9725): 1525-1535

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